Coverage Explorer Help
覆盖度探索器
Inspect sequence coverage across samples and cell groups
Coverage searches split a genomic region or pasted sequence into probes, search them across Malva, and summarize signal by genomic position, sample, cell type, and selected metadata columns.
1
Start with a region or sequence
- Use Region / gene to enter coordinates such as chr11:67435510-67439682, or a gene name that resolves to coordinates.
- Use Sequence for custom DNA, pathogen sequence, variants, or FASTA input.
- The browser shows the selected locus; zoom or drag-select to refine the interval before searching.
2
Read the coverage table
- Each row is a grouped summary, usually cell type plus any visible metadata columns.
- The mini-track shows normalized coverage over the searched positions; smoothing affects display only.
- Cell count and sample count indicate support. Sort and filter before interpreting sparse patterns.
3
Use browser tracks and filters
- Click the track button in a row to add that group to the genome browser.
- Add metadata columns to compare organs, diseases, studies, or finer cell groups.
- Use enrichment as a quick screen for metadata values over-represented in high-coverage rows.
4
Export and cell-level workarounds
- Coverage exports are aggregate tracks, not a dedicated all-cells coverage endpoint.
- For a cell-level approximation, submit overlapping sliding-window probes with malva-client search_sequences(), then call retrieve_cells() on that search job.
- Fetch denominator cells separately with get_cells_by_metadata() when you need fractions or means including zeros.
Before trusting a coverage pattern
Check cell support
Check smoothing
Check filters
Compare browser tracks
详情
拖放 FASTA 文件以搜索